HIV-1 integrase inhibitor 8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

HIV-1 integrase inhibitor 8 是 HIV-1 整合酶 (HIV-1 integrase) 抑制剂，化合物 8。

HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8.

HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 μM and 200 μM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 μM.The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 μM and 200 μM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells.

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Microbiology/Virology

HIV

HIV Protease

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1568-80-5

308.41

C21H24O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (405.30 mM; 超声助溶 )

CC1(C)CC2(CC(C)(C)c3ccc(O)cc23)c2cc(O)ccc12

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(-20℃)

With Ice Pack

≥ 2 years