Zalcitabine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种嘧啶类似物逆转录酶抑制剂 (NRTI)，用于治疗 HIV/AIDS。

A pyrimidine analog reverse transcriptase inhibitor (NRTI) for the treatment of HIV/AIDS; also incorporates into the viral DNA, hence terminating the chain elongation due to the missing hydroxyl group; highly oral activity.HIV Infection Approved(In Vitro):Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.

Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells.

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ddC | Dideoxycytidin

Microbiology/Virology

HIV

HIV

Infection

HIV Infection

7481-89-2

211.2178

C9H13N3O3

>98% (HPLC)

DMSO: 16.67 mg/mL

O=C1N=C(N)C=CN1[C@@H]2O[C@H](CO)CC2

Cytidine, 2',3'-dideoxy-

(-20℃)

With Ice Pack

≥ 2 years