NLRP3/AIM2-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NLRP3/AIM2-IN-3 (compound 59) 是一种有效的抑制剂，对 NLRP3 和 AIM2 炎性体依赖性细胞焦亡 (pyroptosis) 具有不同的物种特异性作用。NLRP3/AIM2-IN-3 对 LPS/nigericin 刺激的 THP-1 巨噬细胞的细胞焦亡具有抑制作用，IC50 为 0.077 ± 0.008 μM。NLRP3/AIM2-IN-3 干扰 NLRP3 或 AIM2 与衔接蛋白 ASC 的相互作用并抑制 ASC 寡聚化。

NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization.

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NF-κB

NOD

NOD | AIM2

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1787787-60-3

266.29

C16H14N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (938.83 mM; 超声助溶 ) Methanol 中的溶解度 : 50 mg/mL (187.77 mM; 超声助溶)

Oc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1

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(-20℃)

With Ice Pack

≥ 2 years