Nigericin sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nigericinodium salt 是一种来自吸水链霉菌的抗生素，是一种 NLRP3 激活剂。

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus and is a NLRP3 activator.Nigericin sodium is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria.?It also prevents viral activation and triggers activation of the NALP3 inflammasome.A 48-hr exposure of human erythrocytes to nigericin significantly increased the percentage of annexin-V-binding cells (0.1-10 nM), significantly decreased forward scatter (0.1-1 nM), significantly decreased cytosolic pH (0.1-1 nM) and significantly increased Fluo3 fluorescence (0.1-10 nM).?Nigericin (1 nM) slightly, but significantly, increased ROS, but did not significantly modify ceramide abundance.?The effect of nigericin on annexin V binding was significantly blunted, but not abolished by removal of extracellular Ca(2+).?The nigericin-induced increase in [Ca(2+)]i and annexin V binding was again significantly blunted but not abolished by the Na(+)/H(+) exchanger inhibitor cariporide (10 μM).?Nigericin triggers eryptosis, an effect paralleled by ROS formation, in part dependent on stimulation of Ca(2+) entry, and involving the cariporide-sensitive Na(+)/H(+) exchanger.

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NF-κB

NOD

NLRP3

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28643-80-3

746.94

C40H67NaO11

>98% (HPLC)

Ethanol:47 mg/mL (62.92mM); Methanol:122 mg/mL (163.33mM; Need ultrasonic)

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(-20℃)

With Ice Pack

≥ 2 years