Eflornithine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Eflornithine (DFMO) 是酶鸟氨酸脱羧酶的特异性不可逆抑制剂。Eflornithine 可用于研究非洲锥虫病和女性面部毛发过度生长。

Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

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Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

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Microbiology/Virology

Parasite

Parasite

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70052-12-9

182.17

C6H12F2N2O2

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 83.33 mg/mL (457.43 mM; 超声助溶 (<60°C)

O=C(O)C(N)(CCCN)C(F)F

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(-20℃)

With Ice Pack

≥ 2 years