MPP+ iodide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MPP+ 碘化物是神经毒素 MPTP 的代谢产物，通过选择性破坏黑质中的多巴胺能神经元，在动物模型中引起帕金森病 (PD) 症状。

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:1, 2, 3 mM Incubation Time:24 hours Result:SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.

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Autophagy

Autophagy

Autophagy

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36913-39-0

297.13

C12H12IN

>98% (HPLC)

DMSO:62.5 mg/mL (210.34 mM; Need ultrasonic);Water:100 mg/mL (336.54 mM; Need ultrasonic)

C[n+](cc1)ccc1-c1ccccc1.[I-]

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(-20℃)

With Ice Pack

≥ 2 years