021-51111890
购物车（）
sales@molnova.cn
K6PC-5
CAS No. 756875-51-1
K6PC-5 ( —— )
产品货号. M34304 CAS No. 756875-51-1
K6PC-5，一种神经酰胺衍生物，是一种鞘氨醇激酶 1 (SPHK1) 激活剂，可引起细胞内钙水平的短暂快速升高。K6PC-5 用于研究涉及异常角质形成细胞的皮肤疾病、神经退行性疾病和病毒感染。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥787 | 有现货 |
|
| 10MG | ￥1169 | 有现货 |
|
| 25MG | ￥2306 | 有现货 |
|
| 50MG | ￥3236 | 有现货 |
|
| 100MG | ￥4383 | 有现货 |
|
| 200MG | ￥6084 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥594 | 有现货 |
|
生物学信息
-
产品名称K6PC-5
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述K6PC-5，一种神经酰胺衍生物，是一种鞘氨醇激酶 1 (SPHK1) 激活剂，可引起细胞内钙水平的短暂快速升高。K6PC-5 用于研究涉及异常角质形成细胞的皮肤疾病、神经退行性疾病和病毒感染。
-
产品描述K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the potential for skin diseases involving abnormal keratinocyte, and neurodegeneration and virus infection research.
-
体外实验Western Blot Analysis Cell Line:Normal human epidermal keratinocytes (NHEKs)Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Increased the involucrin and loricrin levels in a dose-dependent manner.Cell Proliferation Assay Cell Line:Human fibroblasts Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 h Result:Promoted fibroblast proliferation and procollagen production in human fibroblasts significantly.
-
体内实验Animal Model:Intrinsically aged hairless mice (56 weeks old) Dosage:1% (vehicle (PEG:EtOH = 7:3)) Administration:Topical application; twice daily for 2 weeks Result:Enhanced fibroblast proliferation, collagen production, and eventually increased dermal thickness.
-
同义词——
-
通路GPCR/G Protein
-
靶点S1P Receptor
-
受体S1P Receptor
-
研究领域——
-
适应症——
化学信息
-
CAS Number756875-51-1
-
分子量343.5
-
分子式C19H37NO4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (291.12 mM; 超声助溶 )
-
SMILESCCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43.??
