CYM50308

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CYM50308 是 1-磷酸鞘氨醇受体 4 (S1P4-R) 的高亲和力激动剂 (EC50: 56 nM)。

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more selective for S1P4-R than S1P5-R.(In Vitro):The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function.

The disclosed lead molecule CYM50308 (Compound 24f) displays low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P-Rs subtypes. Noteworthy, CYM50308 provides a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the in vivo receptor function.

——

——

GPCR/G Protein

S1P Receptor

S1P4|S1P5

——

——

1345858-76-5

405.46

C20H21F2N3O2S

>98% (HPLC)

DMSO:12 mg/mL?(29.60 mM;?Need ultrasonic)

O=C1N(C)/C(S/C1=C\C2=C(C)N(C3=CC=C(F)C=C3F)C(C)=C2)=N/CCOC

——

(-20℃)

With Ice Pack

≥ 2 years