SB 216641 hydrochloride ( —— )

产品货号. M33924 CAS No. 193611-67-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SB 216641 hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SB-216641A (SB-216641 hydrochloride) 是一种选择性的 5-HT1B/D 受体拮抗剂。SB-216641A 对 h5-HT1B 受体比 h5-HT1D 受体具有高亲和力和选择性。SB-216641A 阻碍 SKF-99101H 在体内的功能。
产品描述

SB-216641A (SB-216641 hydrochloride) is a selective antagonist of 5-HT1B/D receptor. SB-216641A shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors. SB-216641A inhibits the function of SKF-99101H.
体外实验

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体内实验

Animal Model:Guinea pigs.Dosage:0.6, 2.0, 6.0 and 20.0 mg/kg.Administration:Intraperitoneal injection; single dose.Result:Significantly blocked the effects of SKF-99101H.Animal Model:Dogs.Dosage:559 nmol/kg. Administration:Intravenous injection; single dose.Result:Improved the gastric relaxation.
同义词

——
通路

GPCR/G Protein
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

——
适应症

——

CAS Number

193611-67-5
分子量

523.02
分子式

C28H31ClN4O4
纯度

>98% (HPLC)
溶解度

——
SMILES

Cl.O=C(NC1=CC=C(OC)C(OCCN(C)C)=C1)C=2C=CC(=CC2)C=3C=CC(=CC3C)C4=NOC(=N4)C
化学全称

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1. Hagan JJ, et al. Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol. 1997 Jul 23;331(2-3):169-74. ?

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