ICI 162,846

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ICI 162846 是 H2 受体 (receptor) 的口服活性拮抗剂。ICI 162846 在慢性十二指肠溃疡(chronic duodenal ulcer, CDU) 模型中抑制酸的产生并伴随组胺分泌的增加。ICI 162846 能有效预防慢性十二指肠溃疡。

ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU.

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Animal Model:CFLP mice were irradiated to the lower mediastinum to induce CDU.Dosage:10 mg/kg, twice daily for 5 days Administration:Oral gavage (p.o.)Result:Reduced the incidence of CDU. Inhibited gastric acid secretion about 50% or more in the basal and the stimulated periods.Induced massive rises in basal (12-fold) and stimulated (9-fold) luminal histamine.

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GPCR/G Protein

Histamine Receptor

Histamine Receptor

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84545-30-2

306.29

C11H17F3N6O

>98% (HPLC)

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O=C(N)CCCCN1N=C(C=C1)NC(=N)NCC(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years