AEG 3482

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AEG3482 是一种有效的抗凋亡化合物，可诱导热休克蛋白 70 (HSP70) 的表达来抑制 JNK 活性。AEG3482 通过直接结合 HSP90，从而促进 HSP70 和 HSP25 的 HSF1 依赖性表达。

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ～20 μM.AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner. AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells.Apoptosis Analysis Cell Line:PC12 cells Concentration:1, 2.5, 5, 10, 20, 40, 80 μM Incubation Time:40 hours Result:Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM.Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM.Western Blot Analysis Cell Line:PC12 cells Concentration:10, 20, 40 μM Incubation Time:30 hours Result:Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein.

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Apoptosis

Apoptosis

Apoptosis

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63735-71-7

280.33

C10H8N4O2S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (891.81 mM; 超声助溶 )

NS(=O)(=O)c1nn2cc(nc2s1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years