Z-LEHD-fmk

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Z-LEHD-FMK 是一种选择性和不可逆的 caspase-9 抑制剂，可防止致命的再灌注损伤并减弱细胞凋亡。Z-LEHD-FMK 在大鼠脊髓损伤模型中也表现出神经保护作用。

Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma.

Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity.Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.Apoptosis Analysis Cell Line:SW480, H460, HCT116 and 293 cells Concentration:20 μM Incubation Time:Pretreated for 30 min Result:Protected HCT116 and 293 cells from TRAIL-induced apoptosis.Western Blot Analysis Cell Line:HCT116, SW480 cells Concentration:20 μM Incubation Time:2 h Result:Protected procaspase 3 from cleavage in HCT116 cells but not in SW480 cells, especially at the 16-h time point.

Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.Animal Model:Male Wistar albino rats (250-350 g) with SCI Dosage:0.8 μmol/kg Administration:I.v. for 1 or 7 days Result:Decreased the mean apoptotic cell count at 24 hours and 7 days postinjury.

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Apoptosis

Caspase

Caspase | Apoptosis

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210345-04-3

690.72

C32H43FN6O10

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (144.78 mM; 超声加热助溶 )

COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

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(-20℃)

With Ice Pack

≥ 2 years