Ac-YVAD-CHO

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ac-YVAD-CHO (L-709049) 是一种有效的、可逆的、特异性的四肽白介素 1β 转化酶 (ICE) 抑制剂，对小鼠和人类 ICE 的 Ki 值分别为 3.0 和 0.76 nM。Ac-YVAD-CHO 也是一种 caspase-1 抑制剂。Ac-YVAD-CHO 可抑制成熟 IL-lβ 的产生。

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

Western Blot Analysis Cell Line:SNAP-treated thymocytes Concentration:15.6 μM Incubation Time:12 h Result:Reduced PARP cleavage.

Animal Model:P. acnes-sensitized miceDosage:50 mg/kg Administration:I.p.; Result: Suppressed IL-1β levels in blood.Animal Model:Quinolinic acid-treated RatsDosage:2-8 μg Administration:Intrastriatal infusion. Result:Attenuated Quinolinic acid (QA)-induced increases in p53 and apoptosis in rat striatum.Inhibited QA-induced increases in caspase-1 activity and p53 protein levels, with no effect on QA-induced IκB-α degradation, NF-κB or AP-1 activation.

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Apoptosis

Caspase

Caspase | Apoptosis

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143313-51-3

492.52

C23H32N4O8

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : ≥ 50 mg/mL (101.52 mM)

[C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)(C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C)=O)C(C)C

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(-20℃)

With Ice Pack

≥ 2 years