Selamectin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Selamectin 是伊维菌素的大环内酯衍生物，伊维菌素是一种驱虫药，可增强线虫中谷氨酸和 GABA 门控氯离子通道的开放。

Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.(In Vitro):The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.(In Vivo):A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.

The transport of radiolabelled Selamectin through Caco-2 monolayers shows that Selamectin is P-glycoprotein (P-gp) substrates with a secretory/absorptive ratio of 4.7. Selamectin inhibits the efflux of Rh-123 from peripheral blood lymphocytes (PBL) and the concentration of inhibition is similar to that of Verapamil.

A single administration of 6 mg/kg topical Selamectin given every two months could effectively prevent B. malayi infection in cats. Application of topical Selamectin twice a year could block circulating microfilariae.

Selamectin | Revolution | Stronghold

Apoptosis

Caspase

Others

Others-Field

——

220119-17-5

769.96

C43H63NO11

>98% (HPLC)

DMSO : 100 mg/mL 129.88 mM

C/C/1=C\C[C@@H]2C[C@H](OC(=O)[C@H]3[C@@]4(/C(=C/C=C/[C@@H]([C@@H]1O[C@H]1C[C@H](OC)[C@@H](O)[C@H](C)O1)C)/CO[C@@H]4/C(=N\O)/C(=C3)C)O)C[C@]1(CC[C@H](C)[C@@H](C3CCCCC3)O1)O2

A name could not be generated for this structure.

(-20℃)

With Ice Pack

≥ 2 years