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ZED-1227
CAS No. 1542132-88-6
ZED-1227 ( —— )
产品货号. M33535 CAS No. 1542132-88-6
ZED-1227 是一种特异性的，具有口服活性的转谷氨酰胺酶 2 (TG2) 抑制剂，IC50值为 45 nM。ZED-1227 能阻塞炎症诱导的 TG2 表达和激活，可用于乳糜泻的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥6166 | 有现货 |
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| 10MG | ￥8313 | 有现货 |
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| 25MG | ￥11997 | 有现货 |
|
| 50MG | ￥16275 | 有现货 |
|
| 100MG | ￥21240 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ZED-1227
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ZED-1227 是一种特异性的，具有口服活性的转谷氨酰胺酶 2 (TG2) 抑制剂，IC50值为 45 nM。ZED-1227 能阻塞炎症诱导的 TG2 表达和激活，可用于乳糜泻的研究。
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产品描述ZED-1227 is a specific and orally active transglutaminase 2 (TG2) inhibitor,with an IC50 of 45 nM. ZED-1227 can block inflammation-induced TG2 expression and activity. ZED-1227 can be used for the research of celiac disease (CeD).
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体外实验ZED-1227 (0.1 μΜ-1 μΜ; 24 hours) has no effect on metabolic activity and proliferation in Huh7 cells and CaCo2 cells,that suggests ZED-1227 has no cytotoxic activity.?ZED-1227 (0.002-0.2 mg/mL; 30 minutes) inhibits TG2 in the small intestinal mucosa in vitro.
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体内实验ZED-1227 reduces the activity of intestinal TG2 induced by Polyinosinic:Polycytidylic acid (40 mg/kg) to normal control levels and subdues intestinal inflammation in mice.?ZED-1227 (5 mg/kg; i.g.) is able to inhibit TG2 in the small intestinal mucosa.Animal Model:BALB/c miceDosage:5 mg/kg Administration:Oral gavage Result:Inhibited TG2 in vivo in the small intestinal mucosa.
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同义词——
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通路Others
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靶点Other Targets
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受体Glutaminase
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研究领域——
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适应症——
化学信息
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CAS Number1542132-88-6
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分子量528.6
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分子式C26H36N6O6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (236.47 mM; 超声助溶 )
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SMILESCCC(CC)CNC(=O)Cn1cccc(NC(=O)[C@H](CC\C=C\C(=O)OC)NC(=O)c2cncn2C)c1=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Manu Encalada, et al. The Oral Transglutaminase 2 (TG2) Inhibitor Zed1227 Blocks TG2 Activity in a Mouse Model of Intestinal Inflammation. Gastroenterology. 154(6):S-490.
产品手册
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