BMS-986260 是一种选择性、口服生物可利用的 TGFβR1 抑制剂 (IC50 = 1.6 nM)。 BMS-986260 在多种 TGFβ 依赖性细胞测定中表现出功能活性、优异的激酶组选择性、良好的药代动力学特性以及与抗 PD-1 抗体联合在小鼠结直肠癌 (CRC) 模型中的体内疗效。

地塞米松磷酸二钠是合成糖皮质激素地塞米松的水溶性形式。

Bacterial Substrate III, Abz/DNP TFA is an internally quenched fluorescent peptide substrate. Staphylococcus aureus transpeptidase sortase A (SrtA) reacts with its native substrate Bacterial Sortase Substrate III, Abz/DNP, cleaving it and catalyzing the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges.