Oxyphenbutazone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Oxyphenbutazone 是一种保泰松 (Phenylbutazone; HY-B0230) 代谢物，具有抗炎作用。Oxyphenbutazone 是一种具有口服活性的非选择性 COX 抑制剂。Oxyphenbutazone 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。

Oxyphenbutazone is a Phenylbutazone (HY-B0230) metabolite, with anti-inflammatory effect. Oxyphenbutazone is an orally active non-selective COX inhibitor. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.

Oxyphenbutazone enhances the anticancer efficiency of Methotrexate (MTX) (HY-14519) in Hep3B cells.Oxyphenbutazone (2.5-7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.Oxyphenbutazone exhibits reparative effects in the hepatocytes.Cell Cytotoxicity Assay Cell Line:Hep3B cells Concentration:2.5 μM, 5 μM, 7.5 μM Incubation Time:48 hours Result:Enhanced the cytotoxicity of MTX.

Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).Animal Model:Wistar strain albino male rats (5-6 weeks; 150-220 g) Dosage:70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) Administration:PO; once a week; in two divided doses; for 13 weeks Result:Exerted potential anticancer activity in rats when co-treatment with MTX.

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Chromatin/Epigenetic

COX

COX

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129-20-4

324.37

C19H20N2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (308.29 mM; 超声助溶 )

CCCCC1C(=O)N(N(C1=O)c1ccc(O)cc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years