Fedovapagon ( —— )

产品货号. M33357 CAS No. 347887-36-9

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HPLC

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产品名称

Fedovapagon
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Fedovapagon (VA106483) 是一种选择性的加压素 V2 受体 (V2R) 激动剂，EC50 值为24 nM。Fedovapagon 可用于夜尿症的研究。
产品描述

Fedovapagon (VA106483) is a selective and orally active vasopressin V2 receptor (V2R) agonist with an EC50 of 24 nM. Fedovapagon can be used in the research of nocturia.
体外实验

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体内实验

Fedovapagon (1 mg/kg, oral administration) inhibits urine output with 81% inhibition rate in rats.Animal Model:Brattleboro rats Dosage:1 mg/kg, 3 mg/kg Administration:Oral administration Result:Reduced urine volume with almost full inhibition of urine output for 2 h.Returned the urine to normal levels 5 h after dosing.
同义词

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通路

GPCR/G Protein
靶点

Vasopressin Receptor
受体

Vasopressin Receptor
研究领域

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适应症

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1. Yea CM, et al.New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34.?

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