RG7713

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RG7713 (RO5028442, RG-7713) 是一种有效、高选择性、脑渗透性 vasopressin 1a（hV1a 受体）拮抗剂，Ki 为 1 nM。

RG7713 (RO5028442, RG-7713) is a potent, highly selective, brain-penetrant vasopressin 1a (hV1a receptor) antagonist with Ki of 1 nM, shows no activiity on hV2 receptor (Ki>30 uM); displays moderate mouse affinity and excellent selectivity versus hV2 and hOT receptors.Other Indication Phase 1 Clinical(In Vitro):RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.

RG7713 (RO5028442) (compound 8) has excellent binding in and functional affinity for hV1a, moderate mouse affinity, and excellent selectivity versus human V2 (hV2) and human oxytocin (hOT) receptors. RG7713 (RO5028442) shows high solubility. RG7713 (RO5028442) is found to be highly selective against a panel of 89 targets. Finally, RG7713 (RO5028442) is identified as a suitable compound for clinical studies.

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RO-5028442 | RG-7713

GPCR/G Protein

Vasopressin Receptor

hV1areceptor|mV1areceptor

Other Indications

Other Disease

920022-47-5

437.97

C25H28ClN3O2

>98% (HPLC)

DMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(C1=CN(CCN(C)C)C2=C1C=CC(Cl)=C2)N3CCC4(CC3)OCC5=C4C=CC=C5

(6-Chloro-1-(2-(dimethylamino)ethyl)indol-3-yl)-spiro(1H-isobenzofuran-3,4'-piperidine)-1'-yl-methanone

(-20℃)

With Ice Pack

≥ 2 years