OPC-28326

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OPC-28326 是一种外周血管扩张药，同时为 α2-adrenergic receptor 的拮抗剂，对 α2A-，α2B- 和 α2C 肾上腺素受体的 Ki 值分别为 2040，285 和 55?nM。

OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55?nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

OPC-28326 enhances endothelial tube formation and promotes microvessel growth. OPC-28326 induces phosphorylation of eNOS and Akt in HAECs in a dose dependent-manner, while it does not affect total amounts of eNOS and Akt. OPC-28326 (1-100?μM) and yohimbine (10-1000?nM) causes a rightward shift in the concentration-response curve of clonidine.

OPC-28326 augments blood flow recovery in murine hindlimb ischemia. OPC-28326 significantly increases the number of histologically detectable capillaries in the ischemic leg. OPC-28326 has no beneficial effects on blood flow recovery in eNOS?/? mice. OPC-28326 (3-30?mg/kg, i.v.) and yohimbine causes dose-dependent rightward shift in the pressor dose-response curve induced by B-HT 920. OPC-28326 does not affect on the mydriasis in rats.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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167626-17-7

421.58

C26H35N3O2

>98% (HPLC)

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C(=O)(C1=CC(C)=C(NC(CC)=O)C(C)=C1)N2CCC(N(CCC3=CC=CC=C3)C)CC2

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(-20℃)

With Ice Pack

≥ 2 years