JP1302

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JP1302 是一种选择性的、高亲和力的 α2C 肾上腺受体 (α2C-adrenoceptor) 的拮抗剂，其对人类 α2C 受体的 Kb 值为 16 nM，Ki 为 28 nM。JP1302 具有抗抑郁和类抗精神病作用。JP1302 可用于神经精神障碍和肾功能障碍的研究。

JP1302 is a potent, selective, high affinity antagonist of the α2C-adrenoceptor, with a Kb of 16 nM and a Ki of 28 nM for the human α2C-receptor. JP1302 shows antidepressant and antipsychotic-like effects. JP1302 can be used for neuropsychiatric disorders and renal dysfunction research.

JP1302 shows about 100-fold higher affinity than for α2A or α2B.

JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30?μmol/kg of the antidepressant Desipramine (HY-B1272A).JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats.JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction.Animal Model:Male Sprague Dawley rats (8 weeks old) Dosage:3 mg/kg Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusionResult:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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80259-18-3

368.47

C24H24N4

>98% (HPLC)

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N(C=1C2=C(N=C3C1C=CC=C3)C=CC=C2)C4=CC=C(C=C4)N5CCN(C)CC5

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(-20℃)

With Ice Pack

≥ 2 years