(S)-Thalidomide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S-对映体。(S)-Thalidomide 具有免疫调节，抗炎，抗血管生成和促凋亡作用。(S)-Thalidomide 通过与 cereblon (CRBN) 结合诱导致畸作用。

(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .

(S)-Thalidomide treatment results in a reduction in cell viability in U266 cells with an IC50 of 362 μM.(S)-Thalidomide treatment increased apoptosis in a dose-dependent manner in U266 cells.There are changes in the expression profile of genes involved in angiogenesis and apoptosis, but the changes are most dramatic in the apoptotic genes. In particular, the expression of I-κB kinase is decreased by two-fold, which is associated with a four-fold decrease in NF-κB expression. (S)-Thalidomide increases the Bax:Bcl-2 ratio, alsoincreases I-kB protein levels, and decreases NF-kB activity. A dramatic decrease in Bcl-2 expression with (S)-Thalidomide suggests a possible enhancement of cytotoxic effect if combined with other cytotoxic agents.Cell Viability Assay Cell Line:U266 MM cells Concentration:0 μM, 10 μM, 100 μM, 150 μM, 200 μM, 1000 μM Incubation Time:3 days Result:A reduction in cell viability was observed in U266 cells.Apoptosis Analysis Cell Line:U266 MM cells Concentration:100 μM, 150 μM, 200 μM, 1000 μM Incubation Time:3 days Result:Increased apoptosis in U266 cells.

Thalidomide does cause limb reduction defects in chick embryos as long as the embryos are directly exposed to the drug. The most useful techniques are implanting Thalidomide-soaked beads into the embryo immediately adjacent to the limb territory or soaking presumptive chick limb territories in Thalidomide and then grafting the explants to a host embryo celom. Thalidomide affects the chick limb grafted to a host embryo in a dose response fashion. Furthermore, (S)-Thalidomide is more teratogenic than (R)-Thalidomide.

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Apoptosis

Apoptosis

Apoptosis

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841-67-8

258.23

C13H10N2O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 83.33 mg/mL (322.70 mM; 超声助溶 )

O=C1N(C(=O)C=2C1=CC=CC2)[C@@H]3C(=O)NC(=O)CC3

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(-20℃)

With Ice Pack

≥ 2 years