Flavokawain B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Flavokawain B 是一种天然查耳酮，可诱导雄激素受体阴性、激素难治性前列腺癌细胞系凋亡 (IC50=3-50 uM)。

Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.

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Flavokawain B | Flavokawain-B | FlavokawainB

Apoptosis

Apoptosis

Others

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1775-97-9

284.311

C17H16O4

>98% (HPLC)

Chloroform: Soluble Dichloromethane: SolubleEthyl Acetate: SolubleAcetone: SolubleDMSO: 38 mg/mL (133.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=CC=C2

2-Propen-1-one, 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-phenyl-, (E)-

(-20℃)

With Ice Pack

≥ 2 years