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GYKI 52466 dihydrochloride B
CAS No. 2319722-40-0
GYKI 52466 dihydrochloride B ( —— )
产品货号. M32955 CAS No. 2319722-40-0
GYKI 52466 dihydrochloride 是一种具有口服活性、高选择性和非竞争性的 AMPA/Kainate 受体拮抗剂，其 IC50 值分别为 7.5 和 11 μM。GYKI 52466 dihydrochloride 具有良好的血脑屏障通透性和抗惊厥作用，可用于帕金森病的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥664 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GYKI 52466 dihydrochloride B
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GYKI 52466 dihydrochloride 是一种具有口服活性、高选择性和非竞争性的 AMPA/Kainate 受体拮抗剂，其 IC50 值分别为 7.5 和 11 μM。GYKI 52466 dihydrochloride 具有良好的血脑屏障通透性和抗惊厥作用，可用于帕金森病的研究。
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产品描述GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitive AMPA/kainate receptor antagonist with the IC50 values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research.
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体外实验GYKI 52466 (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons.
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体内实验GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice.Animal Model:Male and female DBA/2 mice tested for sound-induced seizure responses Dosage:1.76-13.2 mg/kg Administration:Intraperitoneal injection; 1.76-13.2 mg/kg; once Result:Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ).
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同义词——
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通路Neuroscience
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靶点GluR
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受体GluR
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研究领域——
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适应症——
化学信息
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CAS Number2319722-40-0
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分子量366.24
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分子式C17H17Cl2N3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 2.78 mg/mL (7.59 mM; 超声助溶 (<60°C)
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SMILESCC1=NN=C(C2=CC=C(N)C=C2)C3=C(C=C4OCOC4=C3)C1.Cl.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. S D Donevan, et al. GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses. Neuron. 1993 Jan;10(1):51-9.?
