FPTQ

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

FPTQ 是 mGluR1 的拮抗剂。FPTQ 是一种合成的异喹啉衍生物。

FPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.Neutrophils translocation in the zebrafish tail-transected model was inhibited by FPTQ.?Neutrophil aggregation was also inhibited by FPTQ in the LPS-stimulated zebrafish model.?Decreased mRNA expression of the pro-inflammatory cytokine genes, interleukin-1β (il-1β) and interleukin-6 (il-6), was found in zebrafish larvae injected with FPTQ.?Additionally, production of nitric oxide was inhibited by FPTQ in RAW264.7 macrophage cells treated with LPS.?Moreover, the mRNA expression of Il-1β and Il-6 suppressed by FPTQ treatment in RAW264.7 macrophage cells, and an enzyme immunoassay showed that FPTQ suppressed the secretion of IL-1β and IL-6 in RAW264.7 cells.?These results demonstrate that FPTQ reduced inflammatory responses and, therefore, suggest that it may be effective as an anti-inflammatory agent.

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Neuroscience

GluR

mGluR1

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1025802-62-3

305.32

C17H12FN5

>98% (HPLC)

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Cc1c(nnn1-c1cccnc1F)-c1ccc2cccnc2c1

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(-20℃)

With Ice Pack

≥ 2 years