ADRA1D receptor antagonist 1 HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。

ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM.

ADRA1D receptor antagonist 1 shows low hERG inhibition.ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .

ADRA1D receptor antagonist 1 (4.4 μg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.Animal Model:Rat with bladder outlet obstruction (BOO)Dosage:4.4 μg/kgAdministration: Intravenous injectionResult:Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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1191908-14-1

337.2

C15H14Cl2N4O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (296.56 mM; 超声助溶 )

Cl.C[C@H](c1cccc(c1)C#N)n1cc(Cl)cc(C(N)=O)c1=N

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(-20℃)

With Ice Pack

≥ 2 years