Alfuzosin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Alfuzosin (SL 77499-10) 是一种口服有效的，具有选择性和竞争性的 α1-肾上腺素受体拮抗剂。Alfuzosin 能放松前列腺和膀胱颈的肌肉，有助于排尿。Alfuzosin 可用于良性前列腺增生 (BPH) 的研究。

Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH).

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Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing.Animal Model:Male Wistar rats (250-450 g).Dosage:10 mg/kg Administration:Oral administration; single.Result:Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.

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GPCR/G Protein

Adrenergic Receptor

Adrenergic Receptor

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81403-80-7

389.45

C19H27N5O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 50 mg/mL (128.39 mM )

COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C1CCCO1

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(-20℃)

With Ice Pack

≥ 2 years