021-51111890
购物车（）
sales@molnova.cn
d[Cha4]-AVP
CAS No. 500170-27-4
d[Cha4]-AVP ( —— )
产品货号. M30752 CAS No. 500170-27-4
Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2746 | 有现货 |
|
| 10MG | ￥4418 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称d[Cha4]-AVP
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
-
产品描述Potent and selective human vasopressin V1B receptor agonist (Ki values are 1.2, 151, 240 and 750 nM for V1B, V1A, Oxytocin and V2 receptors respectively). Stimulates ACTH and corticosterone secretion and exhibits negligible vasopressor activity in vivo.
-
体外实验d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pKi values of 9.68 and 7.68, respectively.d[Cha4]-AVP stimulates [Ca2+]i increase in hV1b-CHO cells with a pEC50 value of 10.05. d[Cha4]-AVP shows pEC50 values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31).
-
体内实验——
-
同义词——
-
通路GPCR/G Protein
-
靶点Vasopressin Receptor
-
受体——
-
研究领域——
-
适应症——
化学信息
-
CAS Number500170-27-4
-
分子量1094.31
-
分子式C50H71N13O11S2
-
纯度>98% (HPLC)
-
溶解度water:1 mg/mL
-
SMILESNC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Derick et al (2002) [1-Deamino-4-cyclohexylalanine] arginine vasopressin: a potent and specific agonist for vasopressin V1b receptors. Endocrinology 143 4655 PMID:
产品手册
关联产品
-
Lixivaptan
Lixivaptan 是一种口服活性、选择性加压素受体 V2 拮抗剂 (Ki = 2.3 nM)。
-
RG7713
RG7713 (RO5028442, RG-7713) 是一种有效、高选择性、脑渗透性 vasopressin 1a（hV1a 受体）拮抗剂，Ki 为 1 nM。
-
Terlipressin Acetate
特利加压素是一种高选择性加压素 V1 受体激动剂，可抑制缺氧和葡萄糖剥夺/再氧合 (OGD/R) 引起的肠上皮细胞损伤 (IEC-6)。
