DAMGO (TFA)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DAMGO is a selective peptide agonist of the μ-opioid receptor .

DAMGO is a selective peptide agonist of the μ-opioid receptor .

DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression.DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO.

DAMGO (i.v., 0.5-2 mg/kg) TFA can produce significant anti-injury effects on injured paws of male Sprague-Dawley rats weighing 200-225 g in a dose-dependent manner, producing an effective and long-lasting analgesic effect.

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Endocrinology/Hormones

Opioid Receptor

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950492-85-0

627.61

C28H36F3N5O8

>98% (HPLC)

H2O : 125 mg/mL (199.17 mM; Need ultrasonic)

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Sequence:Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol

(-20℃)

With Ice Pack

≥ 2 years