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Naltrexone hydrochloride
CAS No. 16676-29-2
Naltrexone hydrochloride ( NIH 8503 )
产品货号. M12543 CAS No. 16676-29-2
一种有效的竞争性 μ、κ、δ 和 σ 阿片受体拮抗剂，MOR、KOR 和 DOR 的 Ki 值分别为 0.0825 nM、0.509 nM 和 8.02 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥138 | 有现货 |
|
| 10MG | ￥182 | 有现货 |
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| 25MG | ￥272 | 有现货 |
|
| 50MG | ￥386 | 有现货 |
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| 100MG | ￥537 | 有现货 |
|
| 500MG | ￥1305 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥228 | 有现货 |
|
生物学信息
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产品名称Naltrexone hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的竞争性 μ、κ、δ 和 σ 阿片受体拮抗剂，MOR、KOR 和 DOR 的 Ki 值分别为 0.0825 nM、0.509 nM 和 8.02 nM。
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产品描述A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.
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体外实验——
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体内实验——
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同义词NIH 8503
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通路Endocrinology/Hormones
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靶点Opioid Receptor
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受体OpioidReceptor
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研究领域Neurological Disease
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适应症Alcoholism
化学信息
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CAS Number16676-29-2
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分子量377.8618
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分子式C20H24ClNO4
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 33 mg/mL
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SMILESC1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
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化学全称Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5α)-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.
2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.
3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
产品手册
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