Alpha-Amyrin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Alpha-Amyrin 是一种胰蛋白酶和胰凝乳蛋白酶的抑制剂，具有抗肿瘤作用。 α-香树脂醇可用于肝脏调节剂的研究。

Alpha-Amyrin is an inhibitor of trypsin and chymotrypsin with antineoplastic effects. alpha-Amyrin can be used in studies about acting as a hepatomodulatory.(In Vitro):Alpha-Amyrin induces the proliferation of human keratinocytes by about 18%.

Cell Viability Assay Cell Line:C2C12 Concentration:1, 10 100 μM Incubation Time:24 h Result:Reduced cell viability at 100 μM.Western Blot Analysis Cell Line:C2C12 Concentration: 10 μM Incubation Time:24 h Result:Increased the mRNA and protein expression of PPARs, GLUT4 and FATP.

Animal Model:High-fructose diet (HFD)-induced metabolic syndrome in ratsDosage:50, 100, 200 mg/kg Administration:p.o.Result:Decreased systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides.Attenuated hepatic oxidative stress as well as micro- and macrovesicular fatty changes in hepatocytes caused by HFD.Animal Model:Scopolamine-Induced Memory Impairment Mice Dosage:2 or 4 mg/kg Administration:p.o.Result:Increased the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β).

α-Amyrin | Viminalol | alpha-Amyrine | alpha-Amyrenol

Metabolic Enzyme/Protease

P450

P450

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638-95-9

426.729

C30H50O

>98% (HPLC)

In Vitro:?Methanol : 1 mg/mL (2.34 mM)

[H][C@@]12[C@@H](C)[C@H](C)CC[C@]1(C)CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C

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(-20℃)

With Ice Pack

≥ 2 years