Verapamil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Verapamil 是一种钙通道阻滞剂，也是一种口服有效的 P-gp 抑制剂。

Verapamil is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.(In Vitro):Verapamil inhibits the EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells with an IC50 of 98.0 μM in a concentration-dependent manner.(In Vivo):Verapamil (1 mg/kg;i.v.) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia. Verapamil(oral) is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.

——

——

NSC 135784 | CP-16533-1 | (±)-Verapamil

Metabolic Enzyme/Protease

P450

Potassium Channel

——

——

52-53-9

454.611

C27H38N2O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (219.97 mM)

COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

——

(-20℃)

With Ice Pack

≥ 2 years