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CYM50358
CAS No. 1314212-39-9
CYM50358 ( —— )
产品货号. M28705 CAS No. 1314212-39-9
N-(4-(氨甲基)-2,6-二甲基苯基)-5 是 1-磷酸鞘氨醇受体 4 (S1P4) 的有效、选择性拮抗剂。 CYM50358 抑制 S1P4，IC50 为 25 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
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| 10MG | ￥1881 | 有现货 |
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| 25MG | ￥3125 | 有现货 |
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| 50MG | ￥4399 | 有现货 |
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| 100MG | ￥5967 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1283 | 有现货 |
|
生物学信息
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产品名称CYM50358
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述N-(4-(氨甲基)-2,6-二甲基苯基)-5 是 1-磷酸鞘氨醇受体 4 (S1P4) 的有效、选择性拮抗剂。 CYM50358 抑制 S1P4，IC50 为 25 nM。
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产品描述N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4?with an IC50?of 25 nM.(In Vitro):N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体PLD1
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研究领域——
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适应症——
化学信息
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CAS Number1314212-39-9
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分子量389.28
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分子式C20H18Cl2N2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (321.11 mM)
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SMILESCc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Amylin (8-37), rat
Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin from pancreatic β-cells.
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PNU-282987
PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems.
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IRBP(668-687) (TFA)
Interphotoreceptor retinoid-binding protein(668-687) TFA is the 668-687 amino acid residue of human Interphotoreceptor retinoid binding protein(IRBP), which can induce uveitis.
