dCBP-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

dCBP-1 是 p300/CBP 的化学降解剂。 dCBP-1 劫持 E3 泛素连接酶 CRBN 以选择性降解 p300/CBP。 dCBP-1 降解 p300/CBP 可有效杀死多发性骨髓瘤细胞。

dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing.(In Vitro):Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 revealed almost complete loss of both CBP and p300 between 10 and 1,000 nM doses. A time course analysis with 250 nM dCBP-1 revealed almost complete degradation of p300/CBP within an hour of treatment. dCBP-1 was also able to induce near-complete p300/CBP degradation across other multiple myeloma cell lines tested, including MM1R, KMS-12-BM, and KMS34.

Western Blot Analysis Cell Line:Multiple myeloma cell line MM1S Concentration:10 nM, 100 nM, 250 nM, 500 nM, 1000 nM Incubation Time:6 hours Result:Revealed rapid degradation with near-complete loss of p300/CBP after 2 hours.

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Chromatin/Epigenetic

Epigenetic Reader Domain

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2484739-25-3

1028.11

C51H63F2N11O10

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (48.63 mM)

CNC(N(CC1)Cc2c1n(C(CC1)CCN1C(CCOCCOCCOCCOCCNc(cc1)cc(C(N3C(CCC(N4)=O)C4=O)=O)c1C3=O)=O)nc2N(CCCc1c2)c1cc(C(F)F)c2-c1cn(C)nc1)=O

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(-20℃)

With Ice Pack

≥ 2 years