CDK12-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CDK12-IN-2 是一种有效的选择性 CDK12 抑制剂，对 CDK12、CDK2、CDK7 和 CDK9 的 IC50 分别为 52 nM、>100 μM、>10 μM 和 16 μM。 CDK12-IN-2可用于CDK12功能的研究。

CDK12-IN-2 is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.(In Vitro):In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h.

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CDK12 inhibitor 2

Angiogenesis

CDK

NF-κB|p38|Antifection|Trypanosoma cruzi|Leishmania tropica

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2244987-03-7

532.64

C32H32N6O2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (93.87 mM)

N(C(NCC1=CC=CC=C1)=O)(C2=CC=C(C=C2)C3=CN(C)C(=O)C=C3)[C@H]4CC[C@H](NC5=CC=C(C#N)C=N5)CC4

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(-20℃)

With Ice Pack

≥ 2 years