SIRT7 inhibitor 97491

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SIRT7 抑制剂 97491 是一种 HDAC 抑制剂，对 SIRT7 具有高特异性 (IC50 = 325 nM)。 SIRT7 抑制剂 97491 通过 caspase 途径促进细胞凋亡。

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.(In Vitro):SIRT7 inhibitor 97491 decreased SIRT7 activity in a dose-dependent manner. SIRT7 inhibitor 97491 induced expression of p53 and its acetylation by inhibited SIRT7. SIRT7 inhibitor 97491 (1-10 μM) reduces cell growth in MES-SA cells, without causing cytotoxicity in HEK293 cells.(In Vivo):In xenograft mice, SIRT7 inhibitor 97491 (2 mg/kg; i.p) inhibited tumor growth. SIRT7 inhibitor 97491 upregulated apoptotic effects through the caspase related proteins and inhibited cancer growth in vivo.

Cell Proliferation Assay Cell Line:Human uterine sarcoma MES-SA cells Concentration:1, 5, 10 μM Incubation Time:72 hours Result:Led to more than 50% decrease in cell proliferation at concentrations of 5 and 10 μM. Cell Cytotoxicity Assay Cell Line:Human embryonic kidney cell line HEK293 cells Concentration:1, 5, 10 μM Incubation Time:24 hours Result:HEK293 cells were almost unaffected.

Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells Dosage:2 mg/kg Administration:Intraperitoneally injected; for 3 weeks, except on weekends. Result:Inhibited cancer growth in vivo.

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Chromatin/Epigenetic

Sirtuin

β-Lactamase

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1807758-81-1

285.73

C15H12ClN3O

>98% (HPLC)

In Vitro:?DMSO : 500 mg/mL (1749.90 mM)

Nc1cccc(Nc2ncc(-c(cc3)ccc3Cl)o2)c1

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(-20℃)

With Ice Pack

≥ 2 years