SIRT2-IN-9

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SIRT2-IN-9 (compound 12) 是 SRIT2 的选择性抑制剂，IC50 值为 1.3 μM。SIRT2-IN-9 抑制 MCF-7 乳腺癌细胞的增殖活性。SIRT2-IN-9 可用于癌症的研究。

SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer.

SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ＞300 μM.SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells.SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein.Cell Proliferation Assay Cell Line:MCF-7 breast cancer cell line Concentration:0-50 μM Incubation Time:72 hours Result:Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells.Western Blot Analysis Cell Line:MCF-7 breast cancer cell line Concentration:6.25, 12.5, 25 and 50 μM Incubation Time:6 hours Result:Dose-dependently increased acetylation of α-tubulin protein.

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Chromatin/Epigenetic

Sirtuin

Sirtuin

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522650-91-5

438.57

C21H22N6OS2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 4.46 mg/mL (10.17 mM; 超声助溶 (<70°C)

CCCn1c2ccccc2c2nnc(SCC(=O)Nc3nc4CCCCc4s3)nc12

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(-20℃)

With Ice Pack

≥ 2 years