021-51111890
购物车（）
sales@molnova.cn
Licostinel
CAS No. 153504-81-5
Licostinel ( ACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446 )
产品货号. M27895 CAS No. 153504-81-5
Licostinel 是一种谷氨酸受体拮抗剂。 Licostinel 可预防永久性局灶性脑缺血。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥547 | 有现货 |
|
| 10MG | ￥853 | 有现货 |
|
| 25MG | ￥1730 | 有现货 |
|
| 50MG | ￥2771 | 有现货 |
|
| 100MG | ￥3888 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥527 | 有现货 |
|
生物学信息
-
产品名称Licostinel
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Licostinel 是一种谷氨酸受体拮抗剂。 Licostinel 可预防永久性局灶性脑缺血。
-
产品描述Licostinel is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.
-
体外实验——
-
体内实验Animal Model:The permanent model of middle cerebral artery occlusion in fisher 344 rats and CD-1 mice. The transient model of focal ischemia in Wistar and Sprague –Dawley rats.Dosage:5 mg/kg bolus 3.5 mg/kg/h for 6h, 10 mg/kg bolus 7.0 mg/kg/h for 6h Administration:A single intravenous injection bolus continuous infusionResult:Decreased infarct size.Animal Model:Male Sprague-Dawley rats Dosage:20, 40, 80 mg/kg for intraperitoneal injection (i.p.) bolus 7 mg/kg/h , 30mins Administration:Intravenous injection (i.v.) bolus continuous infusionResult:Reduced the rate of spreading depression and EEG activity in the rat brain in a dose-dependent manner.
-
同义词ACEA-1021 | ACEA 1021 | ACEA1021 | CGP-63446 | CGP 63446
-
通路Neuroscience
-
靶点GluR
-
受体Nucleoside
-
研究领域——
-
适应症——
化学信息
-
CAS Number153504-81-5
-
分子量276.03
-
分子式C8H3Cl2N3O4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 12.5 mg/mL (45.28 mM)
-
SMILES[O-][N+](=O)c1c(Cl)c(Cl)cc2[nH]c(=O)c(=O)[nH]c12
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Taniguchi T, et al. Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis. Nat Chem Biol. 2018 Nov;14(11):1010-1020.
