Inecalcitol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Inecalcitol 是人类乳腺癌细胞的生长抑制剂。 Inecalcitol 是一种独特的维生素 D3 类似物，Kd 为 0.53 nM。

Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM.(In Vitro):A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow.(In Vivo):Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo.

Western Blot Analysis Cell Line:LNCaP cells Concentration:0.1 nM, 1 nM, 10 nM Incubation Time:48 hours Result:Resulted in decreased expression of both protein and mRNA of Pim-1 in a dose-dependent manner.

Animal Model:Male BNX nu/nu mice (8 weeks of age) injected with LNCaP cells.Dosage:1.3 mg/kg Administration:i.p.; 3 times per week; for 42 days Result:Inhibited androgen-responsive prostate cancer growth in vivo.

TX-522 | TX 522 | TX522

Apoptosis

Apoptosis

HIPK2

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163217-09-2

400.603

C26H40O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (249.63 mM)

C[C@H](CC#CC(C)(C)O)[C@H]1CC[C@@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C[C@H](O)C1

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(-20℃)

With Ice Pack

≥ 2 years