5-BDBD

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-BDBD 是一种有效的选择性 P2X4 受体拮抗剂。 5-BDBD 抑制 rP2X4R 介导的电流，IC50 为 0.75 μM。 5-BDBD完全阻断NTG引起的基础痛觉过敏和急性痛觉过敏。

5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal and acute hyperalgesia induced by NTG.(In Vitro):5-BDBD could be specifically used to discriminate between P2X1R, P2X2aR, P2X2bR, P2X3R, P2X4R, and P2X7R. 5-BDBD inhibits 10 μM ATP-induced currents of rP2X4R-expressing HEK293 cells in a concentration-dependent manner, with an IC50 of 0.75 μM. 5-BDBD displaces rightward the ATP concentration-response curve, with an EC50 of 4.7 to 15.9 μM.(In Vivo):Basal hyperalgesia induced by recurrent NTG injection was completely blocked by 5-BDBD.

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Animal Model:Male C57BL/6 mice Dosage:28 mg/kg Administration:I.p.; daily for 9 days Result:Prevented NTG-induced mechanical hypersensitivity.

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Membrane Transporter/Ion Channel

P2X Receptor

NCX3

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768404-03-1

355.191

C17H11BrN2O2

>98% (HPLC)

In Vitro:?DMSO : 62.5 mg/mL (175.96 mM)

Brc1cccc(c1)C1=NCC(=O)Nc2c1oc1ccccc21

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(-20℃)

With Ice Pack

≥ 2 years