Dimethindene maleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Dimethindenemaleate 是一种组胺 H1 拮抗剂，可用于治疗过敏反应、瘙痒和鼻炎的研究。

Dimethindene maleate is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis.

Dimethindene maleate (1-1000 μM) suppresses the cromakalim-induced/glibenclamide-sensitive K＋ currents in a concentration-dependent and reversible manner with an IC50 value of 29.5 μM.Dimethindene maleate (1-1000 μM) inhibits Y-26763-induced glibenclamide-sensitive K＋ currents with an IC50 value of 49 μM.

Dimethindene maleate (0.25 mg; i.p. once) affects wound healing in mice. Animal Model:C57BL/6 mice with wound healing Dosage:0.25 mg Administration:Intraperitoneal injection; 0.25 mg once Result:Significantly delayed skin wound and only showed wound closure impairment in the initial phase wound healing.

SU 6518 | SU-6518 | UNII-6LL60J9E0O | Dimethindene maleate

GPCR/G Protein

Histamine Receptor

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3614-69-5

408.49

C24H28N2O4

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (306.01 mM)

C1(=C(Cc2c1cccc2)CCN(C)C)[C@@H](c1ncccc1)C.C(\C=C/C(=O)O)(=O)O

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(-20℃)

With Ice Pack

≥ 2 years