RS 8359 ( —— )

产品货号. M26814 CAS No. 105365-76-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RS 8359
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RS 8359 是单胺氧化酶 A (MAO-A) 的可逆抑制剂，对 A:B 酶类型的选择性比约为 2200。
产品描述

RS 8359 is a reversible inhibitor of monoamine oxidase A (MAO-A) with a selectivity ratio of about 2200 for the A:B enzyme types. RS 8359 has antidepressant activity.(In Vivo):RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine, thus effectively eliminating the 'cheese' effect which has contributed to the limited clinical use of the classical monoamine oxidase inhibitors. RS 8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect.
体外实验

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体内实验

RS 8359 shows relatively little effect upon blood pressure when administered together with tyramine. RS-8359 shows little affinity for the common central nervous system receptors and little anticholinergic effect.
同义词

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通路

Metabolic Enzyme/Protease
靶点

MAO
受体

Wnt| β-catenin
研究领域

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适应症

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1.1. Waaler J, et al. Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. Cancer Res. 2011;71(1):197-205.

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