Bifemelane hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Bifemelane 盐酸盐是一种 MAO 抑制剂。

Bifemelane hydrochloride is a MAO inhibitor.

Bifemelane inhibits MAO-A in a dose-dependent manner, with Kis of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.Bifemelane inhibits MAO-B activities in a dose-dependent manner, with Kis of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.

Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg. Animal Model:Wistar male rats (230-270 g) are induced hypothermia by ReserpineDosage:20, 40, 80 mg/kg Administration:A single i.p. Result:Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃.

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Metabolic Enzyme/Protease

MAO

MAO

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62232-46-6

305.84

C18H23NO·HCl

>98% (HPLC)

H2O:<30.58mg/ml;DMSO:<30.58mg/ml

CNCCCCOC1=CC=CC=C1CC2=CC=CC=C2.Cl

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(-20℃)

With Ice Pack

≥ 2 years