MP-A08

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MP-A08 是一种高选择性 ATP 竞争性鞘氨醇激酶 (SPHK1) 抑制剂，同时靶向 SphK1 和 SphK2（Ki：分别为 6.9 ± 0.8 μM 和 27 ± 3 μM）。

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).(In Vitro):MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type. MP-A08 blocks pro-proliferative signaling pathways causes mitochondrial-associated apoptosis in an SK-dependent manner. It also reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis (In Vivo):MP-A08 inhibits the growth of human lung tumour xenografts in mice.

MP-A08 blocks pro-proliferative signalling pathways, induces mitochondrial-associated apoptosis in a SK-dependent manner, and reduces the growth of human lung adenocarcinoma tumours in a mouse xenograft model by both inducing tumour cell apoptosis and inhibiting tumour angiogenesis. MP-A08 inhibit SphK2, cause a decrease in EC barrier integrity in vitro in both cell type.

MP-A08 suppresses the growth of human lung tumor xenografts in mice.

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GPCR/G Protein

S1P Receptor

PHD1

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219832-49-2

519.63

C27H25N3O4S2

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (96.22 mM)

Cc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=N\c1ccccc1NS(=O)(=O)c1ccc(C)cc1

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(-20℃)

With Ice Pack

≥ 2 years