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Semapimod hydrochloride
CAS No. 164301-51-3
Semapimod hydrochloride ( CNI 1493 | AXD-455 )
产品货号. M12498 CAS No. 164301-51-3
Semapimod (CNI 1493;AXD-455) 是一种四价脒腙，作为细胞因子诱导的精氨酸转运和 NO 产生的选择性抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1482 | 有现货 |
|
| 10MG | ￥2556 | 有现货 |
|
| 25MG | ￥4241 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Semapimod hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Semapimod (CNI 1493;AXD-455) 是一种四价脒腙，作为细胞因子诱导的精氨酸转运和 NO 产生的选择性抑制剂。
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产品描述Semapimod (CNI 1493;AXD-455) is a tetravalent guanylhydrazone that acts as a selective inhibitor of cytokine-inducible arginine transport and NO production, inhibits TLR4 signaling (IC50=0.3 uM) by targeting the TLR chaperone gp96; does not inhibit EDRF activity, inhibits nitric oxide synthesis by inflammatory macrophages; prevents the development of carrageenan-induced footpad inflammation, and conferred protection against lethal LPS challenge in mice.Irritable Bowel Syndrome Phase 2 Clinical.
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体外实验——
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体内实验Animal Model:Male OZ rats Dosage:5 mg/kg Administration:I.p; daily for 2 weeks Result:Restored endothelium-dependent vasorelaxation in OZ rats.Animal Model:C57Bl/6 mice (GL261 cells were orthotopically implanted) Dosage:6 mg/kg/day Administration:Intracranially for 1 week, delivered via an osmotic pump Result:Inhibited tumor cell invasion by more than 75%.
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同义词CNI 1493 | AXD-455
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通路Immunology/Inflammation
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靶点TLR
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受体TLR
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研究领域Other Indications
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适应症Irritable Bowel Syndrome
化学信息
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CAS Number164301-51-3
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分子量890.746
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分子式C34H56Cl4N18O2
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纯度>98% (HPLC)
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溶解度In Vitro:?H2O : 2.17 mg/mL (2.44 mM)
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SMILESCC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C.Cl.Cl.Cl.Cl
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化学全称N1,N10-bis(3-(1-(2-carbamimidoylhydrazono)ethyl)-5-(1-(2-carbamimidoylhydrazono)ethyl)phenyl)decanediamide tetrahydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bianchi M, et al. Mol Med. 1995 Mar;1(3):254-66.
2. Bianchi M, et al. J Exp Med. 1996 Mar 1;183(3):927-36.
3. Cohen PS, et al. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3967-71.
产品手册
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