TXNIP-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TXNIP-IN-1 是 TXNIP-TRX 复合物的抑制剂，用于研究 TXNIP-TRX 复合物相关的代谢紊乱（糖尿病）、心血管疾病或炎症性疾病。

TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.(In Vitro):In monocytes, TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF. TXNIP-IN-1 bocks high glucose (HG-induced) TXNIP-TRX complex formation. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets. In THP1 cells, TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression. TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. In MIN6 cells, TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels. TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in the human pancreas 1.1B4 beta cells.

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Others

Other Targets

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1268955-50-5

248.238

C12H12N2O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (201.43 mM)

CC(C)C(N1C(=O)c2ccncc2C1=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years