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SP-8356

CAS No. 1454885-45-0

SP-8356 ( —— )

产品货号. M26459 CAS No. 1454885-45-0

SP-8356 是一种有效的口服活性分化簇 147 (CD147) 抑制剂,具有抗动脉粥样硬化作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥1036 有现货
10MG ¥1663 有现货
25MG ¥2706 有现货
50MG ¥3860 有现货
100MG ¥5049 有现货
200MG ¥6804 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
1 mL x 10 mM in DMSO ¥1093 有现货

生物学信息

  • 产品名称
    SP-8356
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    SP-8356 是一种有效的口服活性分化簇 147 (CD147) 抑制剂,具有抗动脉粥样硬化作用。
  • 产品描述
    SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.(In Vitro):In a time- and dose-dependent manner, SP-8356 (5-10?μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10?μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP .(In Vivo):In a xenograft mouse model, SP-8356 (10?mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth . SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Autophagy
  • 靶点
    Autophagy
  • 受体
    COX-2| ROS
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1454885-45-0
  • 分子量
    300.354
  • 分子式
    C18H20O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    [H][C@@]12C[C@@]([H])(C(\C=C\c3cc(O)c(O)c(OC)c3)=CC1=O)C2(C)C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.
产品手册
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