SP-8356

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SP-8356 是一种有效的口服活性分化簇 147 (CD147) 抑制剂，具有抗动脉粥样硬化作用。

SP-8356 is a potent, orally active inhibitor of cluster of differentiation 147 (CD147) with anti-atherosclerotic effects.(In Vitro):In a time- and dose-dependent manner, SP-8356 (5-10?μM; 48 hours) inhibits the growth of various types of breast cancer cell lines. SP-8356 (10?μM; 48 hours) increases the percentage of MDA-MB231 cells in the S phase and decreases caspase-3 and cleaved PARP .(In Vivo):In a xenograft mouse model, SP-8356 (10?mg/kg; i.p.; every three days until the 42nd day) inhibits tumor growth . SP-8356 (50 mg/kg; p.o.; daily one day after carotid artery ligation for three weeks) prevents the formation of plaque and attenuates its vulnerability.

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Autophagy

Autophagy

COX-2| ROS

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1454885-45-0

300.354

C18H20O4

>98% (HPLC)

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[H][C@@]12C[C@@]([H])(C(\C=C\c3cc(O)c(O)c(OC)c3)=CC1=O)C2(C)C

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(-20℃)

With Ice Pack

≥ 2 years