7-Chlorokynurenic acid ( 7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline )

产品货号. M26039 CAS No. 18000-24-3

7-Chlorokynurenic Acid 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 共激动剂位点的 IC50 为 0.56 μM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥417	有现货
10MG	￥656	有现货
25MG	￥1330	有现货
50MG	￥2623	有现货
100MG	￥3798	有现货
500MG	￥8235	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥719	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

7-Chlorokynurenic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

7-Chlorokynurenic Acid 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 共激动剂位点的 IC50 为 0.56 μM。
产品描述

7-Chlorokynurenic acid is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM and shows antinociceptive actions after neuraxial delivery.(In Vivo):In male Sprague-Dawley rats, 7-Chlorokynurenic acid (10 nM) retardates the development of both the electroencephalographic and motor (17.7 daily stimulations) components of the seizure response.
体外实验

——
体内实验

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
同义词

7-CKA | 7-chloro-4-hydroxy-2-carboxyquinoline
通路

Neuroscience
靶点

GluR
受体

CDK
研究领域

——
适应症

——

化学信息

CAS Number

18000-24-3
分子量

223.61
分子式

C10H6ClNO3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 16.67 mg/mL (74.55 mM)
SMILES

O=C(O)C=1N=C2C=C(Cl)C=CC2=C(O)C1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Okusaka T, Ueno H, Ikeda M, Takezako Y, Morizane C. Phase I study of TAC-101, an oral synthetic retinoid, in Japanese patients with advanced hepatocellular carcinoma. Cancer Sci. 2012 Aug;103(8):1524-30. doi: 10.1111/j.1349-7006.2012.02334.x. Epub 2012 Jun 18. PubMed PMID: 22587457.

计算器

浓度计算器

摩尔计算器

分子量计算器

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