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S 18986
CAS No. 175340-20-2
S 18986 ( —— )
产品货号. M33488 CAS No. 175340-20-2
S 18986 是一种选择性的、口服活性的、脑渗透性的 AMPA-type 受体正向变构调节剂。S 18986 显示啮齿动物具有增强认知能力的特性。S 18986 激活大鼠海马去甲肾上腺素和乙酰胆碱的释放，增强大鼠在物体识别实验中的记忆。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥616 | 有现货 |
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| 10MG | ￥938 | 有现货 |
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| 25MG | ￥2037 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称S 18986
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述S 18986 是一种选择性的、口服活性的、脑渗透性的 AMPA-type 受体正向变构调节剂。S 18986 显示啮齿动物具有增强认知能力的特性。S 18986 激活大鼠海马去甲肾上腺素和乙酰胆碱的释放，增强大鼠在物体识别实验中的记忆。
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产品描述S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests.
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体外实验——
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体内实验S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models .S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation.Animal Model:Middle-aged (14-15-months-old) mice Dosage:0.3, 1, and 10 mg/kg Administration: p.o.Result:Showed antiamnesic properties in middle-aged rodents.
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同义词——
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通路Neuroscience
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靶点GluR
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受体GluR
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研究领域——
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适应症——
化学信息
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CAS Number175340-20-2
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分子量224.28
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分子式C10H12N2O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (445.87 mM; 超声助溶 )
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SMILESO=S1(=O)C=2C(N3[C@@](N1)(CCC3)[H])=CC=CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16(5):e193-212.?
