JBSNF-000088

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JBSNF-000088 是一种烟酰胺 N-甲基转移酶 (NNMT) 抑制剂。它用于治疗代谢紊乱。

JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.

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Animal Model:Mice with high fat diet (HFD)-induced obesityDosage:50?mg/kg Administration:Oral route of administration for four weeks; oral gavage administration and twice daily for four weeks Result:Showed statistically significant reduction in body weight (%) and led to a statistically significant reduction in fed blood glucose on day 21 by oral route of administration. Led to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized by oral gavage administration.Animal Model:C57BL/6 mice Dosage:1 mg/kg (Intravenous administration);10 mg/kg (oral gavage)(Pharmacokinetic Study)Administration:Intravenous administration and oral gavage; for 4 hours Result:Resulted in low plasma clearance of 21?mL/min?kg and the volume of distribution at steady state of 0.7?L/kg, a very short plasma half-life of 0.5?h upon intravenous administration.Resulted in a Cmax of 3568 ng/mL with a Tmax value of 0.5?hours, indicating rapid absorption in the intestine, and half-life of 0.4?hours by oral gavage.

JBSNF 000088 | JBSNF000088

Others

Other Targets

NNMT

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7150-23-4

152.15

C7H8N2O2

>98% (HPLC)

DMSO:100 mg/mL (657.25 mM)

O=C(N)C1=CN=C(OC)C=C1

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(-20℃)

With Ice Pack

≥ 2 years